Study: Finds Caffeine Makes Marijuana More Enjoyable

While researching into how cannabis interacts with other drugs in the brain, scientists inadvertently discovered why coffee and getting high go so well together. Caffeine reinforces the effects with THC, potentially making it more pleasurable.

To get a better grasp of how a substance affects the human brain, scientists sometimes look at the interaction between two drugs. To study THC, researchers gave squirrel monkeys (which have a long history of getting stoned in laboratories) the ability to get high with the pull of a lever, which triggered an intravenous release of THC from a small surgically implanted device.

After making the monkeys plenty familiar with the consequences of pulling the lever, they gave them doses of MSX-3, a water-soluble analog of caffeine. With 1 mg/kg (equivalent to less than half a cup of coffee for the average person), the squirrel monkeys pulled the lever less often than normal; and...

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