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Home 🌿 Medical Cannabis News 🌿 More Pain in Anxiety Sufferers, More Anxiety in Pain Sufferers: Understanding Neurological Triggers 🌿More Pain in Anxiety Sufferers, More Anxiety in Pain Sufferers: Understanding Neurological Triggers
Researchers from the University of Toronto report the discovery of the biological basis that may illuminate the observed connection between pain and anxiety. The study focused on the connections between neurons in the anterior cingulate cortex (ACC) region of the brain. Pain can become chronic as neurons become more efficient at transmitting pain signals via repeated use, a process called “long term potentiation” or LTP. Previous work in animal models of chronic pain demonstrated that LTP occurs in the ACC, and that inhibiting LTP reduces chronic pain. However, how LTP in the ACC differs in chronic pain and anxiety was not known, nor why the 2 would interact to result in more pain in anxiety sufferers, and more anxiety in pain sufferers.
In the latest research, the team identified 2 different forms of LTP that can occur in the same cortical synapse. They were termed pre-LTP and post-LTP because they...
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