The complex effects of nicotine when mixed with cannabis

Tobacco and cannabis have a strange relationship, one that has lasted for centuries but has been continually turbulent. Why do so many people use the two together? As usual with cannabinoid science, the truth is stranger than anything that could be dreamed up.

Differences in effect are widely reported

Many users report subjective differences between the effects of cannabis alone and cannabis when mixed with tobacco.

The most common reported effect of smoking tobacco alongside tobacco is an intensification of the “high”, although some report that tobacco use actually has the opposite effect and reduces the high. Another commonly reported effect is to “calm” the user down from the sometimes anxiety-inducing effects of cannabis.

The biological mechanisms underlying this strange relationship are wildly complex, and are linked to various other processes now known to be related but long believed to be essentially separate. Indeed, the more we learn about these...

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