The Future of Getting High

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Scientists are working on nonaddictive opiates, pills that sober you up, and pot designed to produce certain moods.

In 2014, i walked into a dispensary in Boulder and emerged with something truly surreal: a receipt. For weed. Two years earlier, Colorado had voted to legalize recreational marijuana—reflecting a seismic shift in American attitudes toward the drug. In just two generations, the portion of the population that supports legalization went from 12 percent to 58 percent. Along the way, we’ve seen emerging marijuana markets, new technologies, and the normalization of experiences that were once taboo.

At the same time, though, Americans are succumbing to the dangers of other drugs in ever greater numbers. Substance-use disorders now affect more than 21 million Americans. Drug overdose—especially from heroin and other opiates—is the leading cause of accidental death in the U.S. And nearly a third of all vehicle fatalities are alcohol-related.

On the one hand,...

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