Marijuana and Mental Illness: Low Dopamine Levels May Play a Role

A new review offers further insight into how long-term marijuana use might have a negative impact on mental health, after finding "substantial evidence" that the drug alters the brain's reward system to increase negative emotions and decrease motivation.

The study says there is sufficient evidence to suggest marijuana, or cannabis, reduces levels of dopamine in the brain - a neurotransmitter that plays a key role in learning, movement, motivation, emotion, and reward.

Low dopamine levels have been associated with mood changes, fatiguedepression, and lack of motivation; dopamine deficiency is present in a number of neurological conditions, including Parkinson's disease and attention deficit hyperactivity disorder (ADHD).

Study leader Prof. Oliver Howes, of the Medical Research Council (MRC) Clinical Sciences Center at Imperial College London in the United Kingdom,...

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